The Impact of Tri (2-ethylhexyl) Trimellitate on Renal Functions in Sprague–Dawley Rats

Background: Globally, there is a growing concern over the excessive use of plasticizers and their hazardous effects on human’s organs particularly kidney. Aims and Objectives: This study aims to determine the effects of TOTM on renal functions so it may get used in medical equipment, toys, and food packaging with full knowledge regarding its repercussions. The objective is to determine the levels of serum urea, creatinine, cystatin C and endothelial nitric oxide synthase of Sprague Dawley rats exposed to different doses of TOTM to reach viable results. Materials and Methods: A total number of 30 rats were randomly divided into three groups. Each group comprised of 10 male rats divided as one control group (I) given normal saline with rat pellets, group II 300 mg/kg/day of TOTM and group III 1000 mg/kg/day TOTM in the form of rat pellets. Rats of experimental groups II and III were given TOTM with doses of 300 mg/kg/day and 1000mg/kg /day throughout the experiment via oral route for about four weeks. Results: The result showed an increase in serum urea, creatine and cystatin C level in a dose dependent manner. Conclusion: The study finds an association between exposure to TOTM plasticizer on renal function in proportion to dose.