Three new terpenoid derivatives from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007
Three new terpenoid derivatives (1<i>S</i>,6<i>R</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>1</b>), (1 <i>R</i>,6<i>S</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>2</b>), and (7 <i>R</i>,10<i>R</i>)-11-dehydroxy-iso-10-hydroxysydowic acid (<b>3</b>), along with the known analogues (<i>S</i>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<b>4</b>) and trihydroxybutyl ester of 4-carboxydiorcinol (<b>5</b>) were isolated from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <b>4</b> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <b>1</b>-<b>5</b> and cytotoxicity of <b>1</b>-<b>3</b> were also evaluated.
Authors
- Ke-Yue Wu
- Xiaopu Ren (ORCID: https://orcid.org/0000-0001-9550-4356)
- Shu-Hua Qi
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1080/10286020.2024.2443086
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.45