7α-Fluorooxycodone
A C(7)-fluorinated derivative of oxycodone was obtained for the first time by the electrophilic fluorination of the lithium enolate of oxycodone. The reaction involving Selectfluor proceeds stereoselectively and results in the formation of a single C(7)-epimer. The structure of the newly prepared 7α-fluorooxycodone was confirmed by X-ray diffraction.
Authors
- Maria V. Zelentsova (ORCID: https://orcid.org/0000-0002-6335-0855)
- Irina V. Sandulenko (ORCID: https://orcid.org/0000-0001-6787-7526)
- Alexander F. Smol’yakov (ORCID: https://orcid.org/0000-0002-7228-7093)
- Sergey K. Moiseev (ORCID: https://orcid.org/0000-0002-9104-8725)
- A. A. Ambarsumyan
Publication Details
- Journal
- INEOS OPEN
- Published
- 2024-12-28
- DOI
- https://doi.org/10.32931/io2454a
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 0.00