Efficient Method for Obtaining a Precursor in Non-stereospecific Synthesis of Mianserin and Epinastine

A new method for obtaining one of the precursors in the non-stereospecific synthesis of the drugs mianserin and epinastine, namely, (S,R)-6-(phthalimidomethyl)-6,11-dihydro-5H-dibenzo[b,e]azepine is described, which consists in the cyclization of the intermediate amide in a polyphosphate ester medium (ethyl polyphosphate, PPE).

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Publication Details

Journal
INEOS OPEN
Published
2024-12-28
DOI
https://doi.org/10.32931/io2443a
Primary Topic
Chemical synthesis and alkaloids
Type
article
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article

Efficient Method for Obtaining a Precursor in Non-stereospecific Synthesis of Mianserin and Epinastine

A. V. Toktonov
INEOS OPEN
Chemical synthesis and alkaloids
article

Efficient Method for Obtaining a Precursor in Non-stereospecific Synthesis of Mianserin and Epinastine

A. V. Toktonov
article en

Abstract

A new method for obtaining one of the precursors in the non-stereospecific synthesis of the drugs mianserin and epinastine, namely, (S,R)-6-(phthalimidomethyl)-6,11-dihydro-5H-dibenzo[b,e]azepine is described, which consists in the cyclization of the intermediate amide in a polyphosphate ester medium (ethyl polyphosphate, PPE).

INEOS OPENVol. 7(4-5)
Openalex Percentile: Top 82%
Chemical synthesis and alkaloids
DOIOpen Access PDFOpenAlex
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Efficient Method for Obtaining a Precursor in Non-stereospecific Synthesis of Mianserin and Epinastine — A. V. Toktonov · INEOS OPEN (2024) | TGRS Research Map | TGRS