Fatal dengue virus infection in an unvaccinated traveler
Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection. In the context of this case and vaccination guidance for travelers, we discuss pre-vaccination screening, potential implications for travelers to regions with ongoing outbreaks, and emphasize the importance of serostatus-independent vaccines.
Authors
- Jürgen Steinke
- Henning Gruell (ORCID: https://orcid.org/0000-0002-0725-7138)
- Veronica Di Cristanziano (ORCID: https://orcid.org/0000-0003-1604-8386)
- Jan‐Hendrik Naendrup (ORCID: https://orcid.org/0000-0002-6420-7938)
- Gertrud Steger (ORCID: https://orcid.org/0000-0002-0581-8122)
- Dániel Cadar (ORCID: https://orcid.org/0000-0002-8063-2766)
- Alexander Shimabukuro‐Vornhagen (ORCID: https://orcid.org/0000-0002-2351-7294)
- Roger Grosser
- Alexander Simonis (ORCID: https://orcid.org/0000-0003-2945-9897)
- Rosanne Sprute (ORCID: https://orcid.org/0000-0003-2457-6437)
- Jorge Garcia Borrega (ORCID: https://orcid.org/0000-0003-1326-1560)
- Noëlle Sieg
- Jonas Schmidt‐Chanasit (ORCID: https://orcid.org/0000-0003-4433-0231)
- Lisa Altenrath
- Martin Gabriel
- Jesko Welters
Institutions
- Witten/Herdecke University (DE)
- Universität Hamburg (DE)
- University of Cologne (DE)
- Düsseldorf University Hospital (DE)
- Laboratory Dr. Wisplinghoff (DE)
- German Center for Infection Research (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1007/s10096-024-05021-4
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Universitätsklinikum Köln