THE EFFECT OF CORONARY BYPASS SURGERY ON BLOOD AMINOTHIOLS IN PATIENTS WITH CORONARY HEART DISEASE

Coronary heart disease (CHD) is associated with oxidative stress (OS), in which this balance is disrupted, and the production of ROS outweighs their elimination. The oxidative reaction leads to impaired cell function and may increase the likelihood of complications during or after coronary artery bypass surgery (CABG). In pathophysiological conditions associated with OS, there is a general increase in the need for glutathione in antioxidant reactions, conjugation reactions and reduction of protein disulfides. Data on the effect of CABG on plasma aminothiols are incomplete and contradictory.The plasma pool of aminothiols, on the one hand, has a significant effect on the metabolism of glutathione in the tissues of blood vessels and the heart, and on the other hand, may reflect its disorders. CABG, in turn, can be considered as a procedure that triggers stress and adaptive mechanisms that can have a significant effect on the metabolism of aminothiols. However, to date, data on this effect of CABG are fragmentary. To understand the processes occurring in the aminothiol system in coronary heart disease and CABG, it is important to detect not only shifts in the concentrations of these markers, but also.