The Role of Sex Hormones and Sex Hormone-binding Globulin in Functional Gatrointestinal Disorders: A Bidirectional Two-sample Mendelian Randomization Study
Our study revealed a negative causal relationship between testosterone and IBS risk, and SHBG appears to be inversely associated with FD. This provided new ideas for the prevention and control of IBS, and future research is warranted to elucidate the underlying mechanisms driving these associations and their potential clinical implications.
Authors
- Zhengyang Fan (ORCID: https://orcid.org/0009-0007-3698-5509)
- Shuai Zheng (ORCID: https://orcid.org/0000-0002-9143-4909)
- Hongyu Wang (ORCID: https://orcid.org/0000-0002-0762-5623)
- Zheng Chen (ORCID: https://orcid.org/0000-0002-5791-1740)
- Bo Wen (ORCID: https://orcid.org/0000-0002-3384-9276)
- Feng Xie (ORCID: https://orcid.org/0000-0003-3454-6266)
- Binfang Zeng (ORCID: https://orcid.org/0000-0003-4348-0262)
- Changming Shao
- Zhifu Kou
Institutions
- Xinjiang Medical University (CN)
- Air Force Engineering University (CN)
- Tang Du Hospital (CN)
- Southwest Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal and Liver Diseases
- Published
- 2024-12-28
- DOI
- https://doi.org/10.15403/jgld-5642
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.93