Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age
Our study demonstrated distinct sex-specific and age-associated differences in cardiac structure, function, and transcriptome signature between WD-fed male and female mice.
Authors
- Suren Davitavyan (ORCID: https://orcid.org/0000-0002-3414-5553)
- Lahouaria Hadri (ORCID: https://orcid.org/0000-0001-8108-7993)
- Siras Hakobyan (ORCID: https://orcid.org/0000-0002-6875-2482)
- Susmita Sahoo (ORCID: https://orcid.org/0000-0002-7279-1564)
- Malik Bisserier (ORCID: https://orcid.org/0000-0001-8826-4649)
- Amit Rai (ORCID: https://orcid.org/0000-0002-5715-8541)
- Ani Stepanyan (ORCID: https://orcid.org/0000-0001-8564-8532)
- Tamara Sirunyan
- Agnieszka Brojakowska (ORCID: https://orcid.org/0000-0002-7319-9685)
- David A. Goukassian (ORCID: https://orcid.org/0000-0001-5270-5270)
- Arsen Arakelyan (ORCID: https://orcid.org/0000-0002-6851-1056)
- Mary K. Khlgatian
- Venkata Naga Srikanth Garikipati (ORCID: https://orcid.org/0000-0001-5803-5335)
- Gisane Khachatryan
- Roksana Zakharyan (ORCID: https://orcid.org/0000-0003-3411-7584)
- Shihong Zhang (ORCID: https://orcid.org/0000-0002-9661-1089)
Institutions
- New York Medical College (US)
- Yale University (US)
- Institute of Molecular Biology (AM)
- Temple University (US)
- Icahn School of Medicine at Mount Sinai (US)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1186/s12933-024-02565-9
- Citations
- 9
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Aeronautics and Space Administration
- American Heart Association
- Nuclear Safety and Security Commission
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Brookhaven National Laboratory