HEMATOLOGICAL BLOOD INDICES IN DOGS ARTIFICIALLY INFECTED WITH OPISTHORCHIASIS

Current issue: Volume 24, No. 2 (2024) HEMATOLOGICAL BLOOD INDICES IN DOGS ARTIFICIALLY INFECTED WITH OPISTHORCHIASIS Nurasyl Manapov, Rabiga Uakhit, Lyudmila Lider, Ainura Smagulova, Ainagul Begenova, Vladimir Kiyan ⃰ DOI: https://doi.org/10.59893/abud.24(2).006 Manapov N., Uakhit R., Lider L., Smagulova A., Begenova A., Kiyan V. 2024. Hematological blood indices in dogs artificially infected with opisthorchiasis. Acta Biol. Univ. Daugavp., 2024(2): 207-222. Abstract Northern Kazakhstan is known for its high incidence of opisthorchiasis, a parasitic in­fection affecting both humans and animals. In this study, hematological and biochemical blood indices were assessed in dogs infected with opisthorchiasis to evaluate the disease’s impact on the body. The research involved dogs artificially infected with Opisthorchis felineus metacercariae, with dogs serving as definitive hosts. Blood samples were taken weekly and analyzed to monitor hematological and biochemical changes throughout the infection. Significant deviations from normal blood indices were observed. Eosinophil counts increased early in the infection, peaking on days 10 and 26, while lymphocyte levels rose, indicating an active immune response. Hemoglobin, erythrocyte, and platelet counts showed complex dynamics, with erythrocyte levels tending to decrease over time. Biochemical analysis on day 53 revealed elevated levels of ALT, AST, GGT, bilirubin, and total amylase, indicating significant liver involvement. The study concludes that the observed alterations in hematological and biochemical parameters hold significant diag­nostic and monitoring potential for infections caused by parasites from the Opisthorchiidae family in canines. Keywords: Opisthorchis felineus, metacercariae, dog, hematological and biochemical pa­rameters, animal health. *Corresponding author: Vladimir Kiyan. Laboratory of Biodiversity and Genetic Resources, National Center for Biotechnology, Astana, 010000 Kazakhstan. E-mail: vskiyan@gmail. com. ORCID: https://orcid.org/0000-0001-9787-9151 Nurasyl Manapov. Department of Biology and Biotechnology Al-Farabi Kazakh National University, 050040, Almaty, Kazakhstan Rabiga Uakhit. Laboratory of Biodiversity and Genetic Resources, National Center for Biotechnology, 010000, Astana, Kazakhstan Lyudmila Lider. Department of Veterinary Medicine, S. Seifullin Kazakh Agrotechnical Research University, 010000, Astana, Kazakhstan Ainura Smagulova. Laboratory of Biodiversity and Genetic Resources, National Center for Biotechnology, 010000, Astana, Kazakhstan Ainagul Begenova. Department of Microbiology and Biotechnology, S. Seifullin Kazakh Agrotechnical Research University, 010000, Astana, Kazakhstan Manapov N., Uakhit R., Lider L., Smagulova A., Begenova A., Kiyan V. Hematological blood indices in dogs artificially infected with opisthorchiasisDownload