In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson's disease models
This study provides an efficient therapeutic strategy to attenuate LRRK2-induced neurodegeneration and neuroinflammation in PD mouse models, and may open a new avenue to safely deliver siRNA into brain after peripheral intravenous injection and facilitate PD treatment.
Authors
- Penglu Chen
- Xi Chen (ORCID: https://orcid.org/0000-0001-7655-3910)
- Hans‐Peter Fuehrer (ORCID: https://orcid.org/0000-0002-4178-0133)
- Lishan Lin (ORCID: https://orcid.org/0000-0001-5962-0712)
- Wanli W. Smith (ORCID: https://orcid.org/0000-0002-6482-5154)
- Heng Huang (ORCID: https://orcid.org/0000-0002-3483-8333)
- Xiaoyi Ji (ORCID: https://orcid.org/0009-0005-8431-7906)
- Tanvikhaa Saravanan
- Jin Liu (ORCID: https://orcid.org/0000-0002-1067-4063)
- Li Zhang (ORCID: https://orcid.org/0000-0001-9216-0092)
- Tiantian Chen (ORCID: https://orcid.org/0000-0001-6090-099X)
- Zhong Pei (ORCID: https://orcid.org/0000-0002-8425-2867)
- Christopher A. Ross
Institutions
- Nanjing University of Chinese Medicine (CN)
- Johns Hopkins University (US)
- Sun Yat-sen University (CN)
- Johns Hopkins Medicine (US)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Controlled Release
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.jconrel.2024.12.045
- Citations
- 9
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 7.25