[Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice].
Parkin deletion causes mitochondrial autophagy disorder to accelerate PD progression and exacerbates neuroinflammation in mice by affecting the PINK1/Parkin signaling pathway, suggesting the important role of Parkin in early pathogenesis of PD.
Authors
- Yangyang Li (ORCID: https://orcid.org/0000-0001-5361-5058)
- Yu Guo (ORCID: https://orcid.org/0000-0002-4889-1362)
- Caiyun Ma (ORCID: https://orcid.org/0000-0002-6781-3036)
- Rui Zhao (ORCID: https://orcid.org/0000-0003-3769-6550)
- Tingting Zhan (ORCID: https://orcid.org/0000-0002-0407-8716)
- Yongxue Wang (ORCID: https://orcid.org/0000-0001-7417-5733)
- Changqing Liu (ORCID: https://orcid.org/0000-0002-5398-6171)
- Chengcheng Jiang (ORCID: https://orcid.org/0000-0002-5197-5444)
- Zilong Chen (ORCID: https://orcid.org/0009-0002-1453-3839)
- Kexin Duan
Institutions
- Bengbu Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.12.11
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article