Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of osteoarthritis
Groups based on dispositional traits and socioeconomic status explain differing clinical outcomes. Consistent with the allostatic load and hormesis inverted U models, one group was in an adaptive health status, 2 groups were showing signs of developing load, and the fourth group showing signs of overload, at risk of worse health outcomes.
Authors
- Kimberly T. Sibille (ORCID: https://orcid.org/0000-0002-8313-0024)
- Jared J. Tanner (ORCID: https://orcid.org/0000-0001-6821-0029)
- Ahmed Rashid (ORCID: https://orcid.org/0000-0002-8443-1240)
- Nicola Sambuco (ORCID: https://orcid.org/0000-0001-8941-1049)
- Roland Staud (ORCID: https://orcid.org/0000-0002-1317-2368)
- Udell Holmes
- Siegfried Schmidt (ORCID: https://orcid.org/0000-0001-5941-6009)
- Brittany Addison
- Song Lai (ORCID: https://orcid.org/0000-0002-9582-6790)
- Christoph N. Seubert (ORCID: https://orcid.org/0000-0003-4502-4201)
- Cynthia Garvan (ORCID: https://orcid.org/0000-0001-9288-9385)
- Roger Benton Fillingim (ORCID: https://orcid.org/0000-0002-7699-8183)
- Angela M. Mickle (ORCID: https://orcid.org/0000-0001-9175-5342)
- Catherine C. Price (ORCID: https://orcid.org/0000-0001-5994-0644)
- Burel R. Goodin (ORCID: https://orcid.org/0000-0002-8159-1310)
- David T. Redden (ORCID: https://orcid.org/0000-0002-1016-272X)
- Jeffrey C. Edberg
- Olivier Barolette
Institutions
- Washington University in St. Louis (US)
- University of Florida Health (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Advanced Imaging Research (United States) (US)
Publication Details
- Journal
- PAIN Reports
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1097/pr9.0000000000001225
- Citations
- 3
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- National Science Foundation
- McKnight Foundation
- National High Magnetic Field Laboratory
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute on Aging
- Division of Materials Research
- High Magnetic Field Laboratory, Chinese Academy of Sciences