Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation
Severe burns can trigger PANoptosis by activating inflammation-induced Caspase-dependent pathways, which can lead to kidney injury in mice. This impairment is exacerbated in the CKD group. However, the administration of dexamethasone can effectively ameliorate kidney injury. These findings have significant implications for predicting the prognosis of kidney function in burn patients and offer a potential therapeutic approach.
Authors
- Xuetao Yan (ORCID: https://orcid.org/0000-0003-3234-6674)
- Mulan Qahar
- Jinqing He
- Zhi‐Wei Lai (ORCID: https://orcid.org/0000-0001-7314-1814)
- Minghui Wang (ORCID: https://orcid.org/0000-0002-4993-6606)
- Zibo Xiong (ORCID: https://orcid.org/0000-0002-0574-3802)
- Sanmu Li
- Guang Yang (ORCID: https://orcid.org/0000-0001-5271-7079)
- Zuying Xiong
- Thu H. Le (ORCID: https://orcid.org/0000-0002-6410-1623)
- Dehua He
Institutions
- University of Rochester Medical Center (US)
- University Town of Shenzhen (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Peking University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e41485
- Citations
- 8
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province