Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway
In conclusion, our findings showed that NE therapy prevented HCEpiC following BAC application by regulating mitochondrial quality control, which is controlled by PINK1/Parkin-dependent mitophagy. Our research suggests a potential targeted treatment for dry eye disease.
Authors
- Changming Feng (ORCID: https://orcid.org/0009-0005-0972-0332)
- Wushuang Wang (ORCID: https://orcid.org/0000-0002-8762-9244)
- Tong Lin
- Yun Yang (ORCID: https://orcid.org/0000-0002-9986-5930)
- Han Zhao (ORCID: https://orcid.org/0000-0002-8243-7411)
- Lan Gong (ORCID: https://orcid.org/0000-0002-3422-0752)
Institutions
- Academy of Medical Sciences (GB)
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Ocular Immunology and Inflammation
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1080/09273948.2024.2447816
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province