Molecular Characterization of δβ Thalassemia/Hereditary Persistence of Fetal Hemoglobin and Its Correlation With Clinical and Hematological Profile; a Single Center Study in North India
The study highlights that high HbF determinants, like δβ thalassemia and HPFH, are relatively more frequent in the Indian subcontinent, and their co-inheritance with β-thalassemia results in a moderately severe disease. Accurate identification of molecular defects is important for prenatal diagnosis and genetic counseling.
Authors
- Ajit J. Shah (ORCID: https://orcid.org/0000-0002-2350-6384)
- Rajesh Kashyap (ORCID: https://orcid.org/0000-0002-6645-8052)
- Manish Kumar Singh (ORCID: https://orcid.org/0000-0001-7558-2656)
- Akhilesh Sharma (ORCID: https://orcid.org/0000-0002-4482-3709)
- Kriti Gupta (ORCID: https://orcid.org/0000-0002-1394-1518)
- Khaliqur Rahman (ORCID: https://orcid.org/0000-0002-8285-2092)
- Sangeeta Yadav (ORCID: https://orcid.org/0000-0002-8895-8138)
- Ruchi Gupta (ORCID: https://orcid.org/0000-0003-3427-9188)
- Dinesh Chandra (ORCID: https://orcid.org/0000-0002-6069-8768)
Institutions
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
Publication Details
- Journal
- International Journal of Laboratory Hematology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1111/ijlh.14419
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Indian Council of Medical Research