The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism
We successfully constructed a novel mouse model for liver fibrosis. This GSDMD-NT-induced fibrosis may be mediated by abnormal lipid metabolism. Our results demonstrated that we successfully constructed a mouse model of liver fibrosis, and GSDMD-NT induced fibrosis by mediating lipid metabolism.
Authors
- Zhihang Zhou (ORCID: https://orcid.org/0000-0003-1356-9872)
- Wei Zhao (ORCID: https://orcid.org/0000-0003-2421-7311)
- Cunxiang Ju
- Dongbo Wu (ORCID: https://orcid.org/0000-0003-4500-047X)
- Peiliang Shi
- Xuemei Ding (ORCID: https://orcid.org/0000-0003-4298-4493)
- Chunyou Ning
- Xue Chao Wang (ORCID: https://orcid.org/0000-0002-2381-9145)
- Lingfeng Wan
- Zhengzhong Wu
- Xingyi Cheng
Institutions
- Nanjing University of Chinese Medicine (CN)
- Dalian Medical University (CN)
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chengdu Organic Chemicals (China) (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ame2.12506
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Chengdu Medical College
- National Natural Science Foundation of China
- Nanjing University of Chinese Medicine
- Nanjing University