The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023. This study was designed to explore clinical practices in the diagnosis and treatment of neurosyphilis. We proposed and validated a new set of diagnostic criteria across 782 cases, comparing three different NS criteria for diagnostic efficiency. Among the 782 patients analyzed, 410 were diagnosed with neurosyphilis, while 372 were not. The newly developed NS criteria demonstrated a sensitivity of 99.5% and a specificity of 94.6%, with the added benefit of being user-friendly. In subgroups categorized by neurological symptoms and syphilis stages, the new NS criteria also exhibited high sensitivity and specificity. Statistical analyses confirmed that the novel NS criteria performed comparably well to the expanded NS criteria. The novel NS criteria for HIV-negative patients exhibited high sensitivity and specificity, proving to be both effective and convenient for physicians to implement.

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Publication Details

Journal
Scientific Reports
Published
2024-12-28
DOI
https://doi.org/10.1038/s41598-024-82477-6
Citations
1
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.33

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article

The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Ligang Yang, Qiwei Zhou, Jianxiong Zhao, Suping Wang et al.
1 citations
Scientific Reports
Syphilis Diagnosis and Treatment
0.33
article

The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Ligang Yang, Qiwei Zhou, Jianxiong Zhao, Suping Wang, Zhe Zhou, Yuye Li, Wenli Feng, Tian‐Ci Yang, Aili Li, Yang Luo, Fangzhi Du, Mingjie Zhang, Dongdong Li, Hongxia Li, Xu Zhang, Lihua Hu, Ying Gao, Xiaoyun Yu, Xiaowen Ma, Yuyuan Ma, Minzhi Wu, M. H. Gu, Jianjun Ren, T. X. Zeng, Ruili Zhang, Qianqiu Wang
article en
1 citations

Abstract

Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023. This study was designed to explore clinical practices in the diagnosis and treatment of neurosyphilis. We proposed and validated a new set of diagnostic criteria across 782 cases, comparing three different NS criteria for diagnostic efficiency. Among the 782 patients analyzed, 410 were diagnosed with neurosyphilis, while 372 were not. The newly developed NS criteria demonstrated a sensitivity of 99.5% and a specificity of 94.6%, with the added benefit of being user-friendly. In subgroups categorized by neurological symptoms and syphilis stages, the new NS criteria also exhibited high sensitivity and specificity. Statistical analyses confirmed that the novel NS criteria performed comparably well to the expanded NS criteria. The novel NS criteria for HIV-negative patients exhibited high sensitivity and specificity, proving to be both effective and convenient for physicians to implement.

Scientific ReportsVol. 14(1)
Shanxi Medical University (CN), Xuzhou Medical College (CN), Jilin University (CN), Nantong University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Sichuan University (CN), Kunming Medical University (CN), West China Hospital of Sichuan University (CN), Ansteel (China) (CN), Second People's Hospital of NanTong (CN), The People's Hospital of Guangxi Zhuang Autonomous Region (CN), Dalian Dermatosis Hospital (CN), First Affiliated Hospital of Kunming Medical University (CN), Zhongshan Hospital of Xiamen University (CN), First Hospital of Jilin University (CN), Second Hospital of Shanxi Medical University (CN), Second Affiliated Hospital of Nanjing Medical University (CN), Xuzhou No.1 People's Hospital (CN), Xian Yang Central Hospital (CN), Nanjing Second Hospital (CN), Chongqing Public Health Medical Center (CN), Wuxi People's Hospital (CN), First People's Hospital of Chongqing (CN), First Hospital of Xi'an (CN), The Fifth People’s Hospital of Suzhou (CN), First People's Hospital of Jingzhou (CN), Huazhong University of Science and Technology (CN), Southern Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 34%
Syphilis Diagnosis and Treatment
0.33
DOIOpen Access PDFOpenAlex
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