Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as a promising approach to regulating cellular fate in regenerative medicine. However, few reviews provide a comprehensive examination of recent advancements in chiral biomaterials and their applications in cellular fate regulation. Herein, various fabrication techniques available for chiral biomaterials, including the use of chiral molecules, surface patterning, and self‐assembly are discussed. The mechanisms through which chiral biomaterials influence cellular responses, such as modulation of adhesion receptors, intracellular signaling, and gene expression, are explored. Notably, chiral biomaterials have demonstrated their ability to guide stem cell differentiation and augment tissue‐specific functions. The potential applications of chiral biomaterials in musculoskeletal disorders, neurodegenerative diseases, cardiovascular diseases, and wound healing are highlighted. Challenges and future perspectives, including standardization of fabrication methods and translation to clinical settings, are addressed. In conclusion, chiral engineered biomaterials offer exciting prospects for precisely controlling cellular fate, advancing regenerative medicine, and enabling personalized therapeutic strategies.