Differences in Cartilaginous Oligomeric Matrix Protein Levels and Lysholm Score 6 Months After Anterior Cruciate Ligament Reconstruction Between Procedure Taken Less Than 6 Weeks and More Than 6 Weeks After Injury

Introduction: Anterior cruciate ligament (ACL) injury is a common problem faced by patients, especially among young athletes. This study aims to evaluate differences in Cartilaginous Oligomeric Matrix Protein (COMP) levels and Lysholm scores six months after ACL reconstruction, based on the time the procedure was performed, namely ≤ 6 weeks after injury compared with > 6 weeks after injury. This research is expected to provide insight into the influence of procedure time on functional outcomes and biomarkers after ACL reconstruction. Materials and Methods: This study involved 30 subjects who underwent ACL reconstruction at Prof IGNG Ngoerah Hospital, with 15 patients undergoing surgery ≤ 6 weeks after injury and 15 other patients > 6 weeks after injury. COMP serum sampling was performed, and the Lysholm score was measured using a questionnaire. Statistical analysis was performed to compare COMP levels and Lysholm scores between the two groups. Results: The results of the study showed that there was a significant difference in COMP levels between patients who underwent ACL reconstruction ≤ 6 weeks after injury compared with those who underwent reconstruction > 6 weeks after injury. Patients who underwent reconstruction earlier showed lower COMP levels, which was associated with higher Lysholm scores, indicating better functional outcomes. However, analysis of the proportion of Lysholm scores showed no significant difference between the two groups, although the proportion of patients with high scores was greater in the early reconstruction group. Conclusion: This study concluded that there was a significant difference in joint fluid COMP levels between patients who underwent ACL reconstruction ≤ 6 weeks after injury compared with > 6 weeks after injury. These results demonstrate the importance of treatment timing in ACL reconstruction to achieve optimal functional outcomes and can be used as a guide in the management of ACL injuries in the future. Keywords: Anterior Cruciate Ligament, Cartilaginous Oligomeric Matrix Protein, Lysholm Score, Rekonstruksi ACL, Knee Injury