Pesticide exposure promotes disease activity by decreasing lymphoproliferative activity and increasing IL-4 production in systemic sclerosis patients
Taken together, our findings indicate that persistent exposure to these OCPs results in decreased lymphoproliferative activity which promotes disease activity by producing pro-fibrotic cytokine(s). Thus, SSc patients are less able to initiate or augment an immune response to foreign antigens, when there is substantial suppression of lymphocyte function, which increases their susceptibility to infection. Strategies to prevent and control pesticide exposure may play an important role in reducing the morbidity and mortality associated with this disease.
Authors
- Arshad Jawed (ORCID: https://orcid.org/0000-0002-3161-9864)
- Ahmad Alsulimani (ORCID: https://orcid.org/0000-0002-2131-9163)
- Naseem Akhter (ORCID: https://orcid.org/0000-0003-2011-0955)
- Mazin A. Zamzami (ORCID: https://orcid.org/0000-0002-6709-3227)
- Salwa Al-Thawadi (ORCID: https://orcid.org/0000-0002-9529-1845)
- Saba Beigh
- Abrar Ahmad (ORCID: https://orcid.org/0000-0001-9439-7712)
- Sajad Ahmad Dar (ORCID: https://orcid.org/0000-0003-2499-8701)
- Basu Dev Banerjee
- Shukla Das
- Mohamed Yahya Alfoud
Institutions
- University of Bahrain (BH)
- University of Delhi (IN)
- University College of Medical Sciences (IN)
- King Abdulaziz University (SA)
- Guru Teg Bahadur Hospital (IN)
- Jahrom University of Medical Sciences (IR)
- Al Baha University (SA)
- Arizona State University (US)
- Jazan University (SA)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1080/08923973.2024.2445731
- Citations
- 3
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Deanship of Scientific Research, Prince Sattam bin Abdulaziz University