Antioxidant and antibacterial activity of root extracts of Georgian medicinal plants obtained using different extraction methods

This study was designed to investigate the impact of different extracting solvents (methanol and DMSO) on the biological activities of root extract of Paeonia daurica subsp. mlokosewitschii (Lomakin) D. Y. Hong and Sempervivum transcaucasicum Muirhead. In vitro assessment of the antioxidant activity of extracts was performed using 2,2-diphenyl-1-picrylhydrazyl (DPPH assays), while their antibacterial activity was tested against Escherichia coli ATCC 25922 strain. The analysis of the obtained results revealed that the highest anti-DPPH potential and the highest antibacterial activity were achieved in the methanolic root extracts of both plants. The methanolic root extracts of Paeonia daurica subsp. mlokosewitschii exhibited significantly higher antioxidant and antibacterial activities in comparison with Sempervivum transcaucasicum root extracts. The results of the study indicated the possible use of root extracts of Paeonia daurica subsp. mlokosewitschii in pharmacy.