Protective Effects of Baicalein and Bergenin Against Gentamicin‐Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study
Baicalein and bergenin significantly mitigated gentamicin-induced hepatic and renal toxicity by restoring biochemical markers, reducing oxidative stress and enhancing antioxidant enzyme activity. Histopathological and immunohistochemical analyses confirmed the protective effects of both compounds against organ damage. No statistically significant differences were observed between the two drugs for these parameters. These results suggest their potential as therapeutic agents to prevent gentamicin-induced organ toxicity.
Authors
- Fazile Nur Eki̇nci̇ Akdemi̇r (ORCID: https://orcid.org/0000-0001-9585-3169)
- Fatih Mehmet Kandemır (ORCID: https://orcid.org/0000-0002-8490-2479)
- Mustafa Can Güler (ORCID: https://orcid.org/0000-0001-8588-1035)
- Ersen Eraslan (ORCID: https://orcid.org/0000-0003-2424-2269)
- Serkan Yıldırım (ORCID: https://orcid.org/0000-0003-2457-3367)
Institutions
- Aksaray University (TR)
- Ağrı İbrahim Çeçen University (TR)
- Bandırma Onyedi Eylül University (TR)
- Atatürk University (TR)
Publication Details
- Journal
- Basic & Clinical Pharmacology & Toxicology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1111/bcpt.14121
- Citations
- 3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.40