A covalent organic framework-based nanoreactor for enhanced chemodynamic therapy through cascaded Fenton-like reactions and nitric oxide delivery
Herein, we report a nanoscale composite COF material loaded with copper peroxide (CuO<sub>2</sub>) and nitric oxide (NO) prodrug <i>via</i> a stepwise post-synthetic modification. The obtained CuO2@COF-SNO can undergo a cascade reaction in the tumor microenvironment to generate reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of the tumor.
Authors
- B. Ge (ORCID: https://orcid.org/0009-0006-3735-0030)
- Yu‐Bin Dong (ORCID: https://orcid.org/0000-0002-9698-8863)
- Tian Song
- Wenyan Li (ORCID: https://orcid.org/0009-0000-6591-1073)
- Jin-Zhou Lv
- Bo Wang (ORCID: https://orcid.org/0000-0002-8908-8891)
- Yanan Li (ORCID: https://orcid.org/0000-0002-7083-4022)
Institutions
- Shandong Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1039/d4cc05939e
- Citations
- 7
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province