CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy
These findings underscore the impact of prior chemotherapy on expanding the pool of senescent T cells, particularly CD57<sup>+</sup> EMRA CD8<sup>+</sup> T and CD57<sup>+</sup> GRZB<sup>+</sup> EMRA CD8<sup>+</sup> T cells, whose expansion could potentially affect the effectiveness of anti-PD-1/PD-L1 immunotherapy in elderly patients. This highlights the need for tailored approaches in this population.
Authors
- Pierre-André Natella (ORCID: https://orcid.org/0009-0003-7584-6123)
- Éléna Paillaud (ORCID: https://orcid.org/0000-0002-5579-9927)
- Axelle Histe
- Pascaline Boudou‐Rouquette (ORCID: https://orcid.org/0000-0002-4860-305X)
- Johanna Canovas
- Éric Tartour (ORCID: https://orcid.org/0000-0002-7323-468X)
- Anis Larbi (ORCID: https://orcid.org/0000-0001-8805-5433)
- Florence Canouï‐Poitrine (ORCID: https://orcid.org/0000-0001-9970-6051)
- Clémence Granier (ORCID: https://orcid.org/0000-0002-4213-6438)
- Philippe Caillet (ORCID: https://orcid.org/0000-0003-3583-6070)
- Richard Layese (ORCID: https://orcid.org/0000-0002-2855-4908)
- Cécile Gonnin
- Johanne Poisson (ORCID: https://orcid.org/0000-0002-0183-845X)
- Besma Saadaoui
- Michelle Leemans (ORCID: https://orcid.org/0000-0002-2028-2610)
- Aurélien Corneau (ORCID: https://orcid.org/0000-0003-1272-6872)
- Hélène Vallet (ORCID: https://orcid.org/0000-0002-3593-5055)
- Pauline Ober
- Morgane Lebraud
- Catherine Blanc (ORCID: https://orcid.org/0000-0003-2665-7417)
- Pierre Gay
- Carine El-Sissy
- Louise Roquebert
Institutions
- Université de Sherbrooke (CA)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Hôpital Européen (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Centre de Recherche sur l'Inflammation (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Paris Cardiovascular Research Center (FR)
- Laboratoire d’immunologie intégrative du cancer (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12979-024-00487-4
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.13