Coronary Plaque Characteristics Assessed by Optical Coherence Tomography and Plasma Lipoprotein(a) Levels in Patients With Acute Coronary Syndrome
In this observational study including ACS patients undergoing OCT-guided PCI, those with elevated Lp(a) levels exhibited a higher prevalence of lipid-rich plaques, increased macrophage infiltration, and TCFA, thereby indicating a more vulnerable plaque phenotype. Additionally, elevated Lp(a) levels and LDL-C levels ≥ 70 mg/dL were each independently associated with lipid enrichment of coronary plaques. These findings suggest Lp(a), beyond other well-known risk factors, as a key marker for risk stratification, potentially informing optimal medical management strategies.
Authors
- Giulia Nardi (ORCID: https://orcid.org/0000-0002-8144-0117)
- Emanuele Cecchi (ORCID: https://orcid.org/0000-0002-7035-9639)
- Alessio Mattesini (ORCID: https://orcid.org/0000-0001-8697-2692)
- Miroslava Stolcova (ORCID: https://orcid.org/0000-0003-2014-7635)
- Elena Bigi
- Maria Federica Crociani
- Carlo Di Mario (ORCID: https://orcid.org/0000-0002-4461-2055)
- Francesca Maria Di Muro (ORCID: https://orcid.org/0000-0002-2145-6555)
- Iacopo Muraca (ORCID: https://orcid.org/0000-0001-5861-5882)
- Lucrezia Biagiotti
- Renato Valenti (ORCID: https://orcid.org/0000-0002-0215-9192)
- Francesca Ristalli (ORCID: https://orcid.org/0000-0002-5961-0837)
- Francesco Meucci (ORCID: https://orcid.org/0000-0003-2719-5146)
- Niccolò Ciardetti (ORCID: https://orcid.org/0000-0003-4226-1084)
Institutions
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- Catheterization and Cardiovascular Interventions
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ccd.31363
- Citations
- 5
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.86