Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery

A prolonged CPB triggers a systemic inflammatory response and activates MMP9, leading to glypican-1 shedding and endothelial dysfunction.

Authors

Ismael Garcia
Nandan K. Mondal (ORCID: https://orcid.org/0000-0003-2999-8567)
Iván Murrieta-Álvarez (ORCID: https://orcid.org/0000-0002-8284-333X)
Randall P. Kirby (ORCID: https://orcid.org/0000-0003-4144-7127)
Todd K. Rosengart
Rajarshi Bhattacharya (ORCID: https://orcid.org/0000-0002-0725-2388)
Katherine V. Nordick
Camila Hochman‐Mendez (ORCID: https://orcid.org/0000-0002-1425-594X)
Kenneth K. Liao (ORCID: https://orcid.org/0000-0002-2101-4925)
Shiyi Li (ORCID: https://orcid.org/0000-0002-1650-3249)

Institutions

Baylor College of Medicine (US)

Publication Details

Journal: Biomedicines
Published: 2024-12-27
DOI: https://doi.org/10.3390/biomedicines13010033
Citations: 9
Primary Topic: Cardiac and Coronary Surgery Techniques
Type: article
Field-Weighted Citation Impact: 5.15

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article

Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery

Ismael Garcia, Nandan K. Mondal, Iván Murrieta-Álvarez, Randall P. Kirby et al.

Dec 27, 2024

9 citations

Biomedicines

Cardiac and Coronary Surgery Techniques

5.15

article

Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery

Ismael Garcia, Nandan K. Mondal, Iván Murrieta-Álvarez, Randall P. Kirby, Todd K. Rosengart, Rajarshi Bhattacharya, Katherine V. Nordick, Camila Hochman‐Mendez, Kenneth K. Liao, Shiyi Li

December 27, 2024article en

9 citations

Abstract

A prolonged CPB triggers a systemic inflammatory response and activates MMP9, leading to glypican-1 shedding and endothelial dysfunction.

BiomedicinesVol. 13(1)

Baylor College of Medicine (US)

No poverty

Openalex Percentile: Top 4%

Cardiac and Coronary Surgery Techniques

5.15

DOI Open Access PDF OpenAlex

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Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery — Ismael Garcia, Nandan K. Mondal, et al. · Biomedicines (2024) | TGRS Research Map | TGRS