Whole-genome Sequencing Analysis of Bile Tract Cancer Reveals Mutation Characteristics and Potential Biomarkers
Our study provides novel insights into the genomic landscape of BTC and highlights the potential of whole-genome sequencing analysis to identify actionable gene mutations and understand the molecular mechanisms underlying this malignancy. The high mutational burden, structural variations, and copy number alterations observed in BTC samples in this study underscore the genetic complexity and heterogeneity of this disease.
Authors
- Shunsuke Onoe (ORCID: https://orcid.org/0000-0002-0498-5586)
- Takashi Mizuno (ORCID: https://orcid.org/0000-0001-8802-1188)
- Shoji Kawakatsu (ORCID: https://orcid.org/0000-0002-6692-552X)
- Tomoki Ebata (ORCID: https://orcid.org/0000-0002-8247-7050)
- Junpei Yamaguchi (ORCID: https://orcid.org/0000-0002-5892-5271)
- Taisuke Baba
- TOSHIO KOKURYO
- Masaki Sunagawa (ORCID: https://orcid.org/0000-0002-8334-1964)
- Nobuyuki Watanabe (ORCID: https://orcid.org/0000-0002-6221-4480)
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2024-12-27
- DOI
- https://doi.org/10.21873/cgp.20484
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Japan Society for the Promotion of Science