Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors
Cancer cells, under immune stress, may acquire both immune escape capabilities and increased immunogenicity. This dual effect could lead to either resistance or response to ICIs, respectively.
Authors
- Takuya Tsunoda (ORCID: https://orcid.org/0000-0002-6416-8211)
- Toshiaki Tsurui (ORCID: https://orcid.org/0000-0002-6167-8953)
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Kiyoshi Yoshimura (ORCID: https://orcid.org/0000-0003-4816-1826)
- Kazuyuki Takeda (ORCID: https://orcid.org/0000-0002-6743-0932)
- Daisuke Takayanagi (ORCID: https://orcid.org/0000-0001-9644-9782)
- Hirotsugu Ariizumi (ORCID: https://orcid.org/0000-0003-1663-8730)
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- Ryotaro Ohkuma (ORCID: https://orcid.org/0000-0003-4121-2491)
- Atsushi Horiike (ORCID: https://orcid.org/0000-0002-1632-3125)
- Masahiko Izumizaki (ORCID: https://orcid.org/0000-0003-4377-8421)
- Tomoyuki Ishiguro
- Masahiro Shimokawa (ORCID: https://orcid.org/0000-0002-8645-4112)
- Nana Iriguchi
- Yuya Hirasawa
- Satoshi Wada (ORCID: https://orcid.org/0000-0003-1276-6620)
- Emiko Mura
- Risako Suzuki
Institutions
- SHOWA Medical University (JP)
- Juntendo University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2024-12-27
- DOI
- https://doi.org/10.21873/cgp.20481
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00