Association of single nucleotide variants of the clock gene (rs1801260) with seizures after alcohol withdrawal

Objective: to study the association of single nucleotide variants of the CLOCK gene (rs1801260) and seizures aſter alcohol withdrawal. Materials and methods: 399 patients were analyzed, including 83 women (21%) and 316 men (79%). The average age of the patients was 41.52±8.42 years. The patients were divided into 2 groups. The main group (patients who suffered a seizure in a hospital setting) consisted of 108 patients, 12 women (11%), 96 men (89%), and the comparison group consisted of 291 patients, 71 (25%) women and 220 (75%) men. The examination of patients took place from February 2019 to August 2023. The laboratory study included a comparative genetic examination of two groups of patients: the first group — patients with alcohol dependence syndrome with seizures aſter alcohol withdrawal (F10.2); the second group — patients with alcohol dependence syndrome (F10.2) without seizures aſter alcohol withdrawal. Statistical processing was carried out using Microsoſt Excel, IBM SPSS Statistics 26. During the frequency analysis, the criterion χ² (Pearson Chi-squared) was used, and the odds ratio for each of the genotypes was estimated. The differences were recognized as statistically significant at a significance level of p<0.05. ><0.05. Results: when conducting a frequency analysis of the occurrence of seizures aſter alcohol withdrawal, carriers of the CC genotype had seizures much less frequently than carriers of other genotypes. Conclusion: the presence of the T allele of the CLOCK gene in the genotype is associated with seizures aſter alcohol withdrawal. Moreover, carriers of the homozygous genotype have a higher chance of experiencing seizures than carriers of the homozygous genotype.