Chronic urinary tract infections cause persistent microglial changes in a humanized ɑ-synuclein mouse model
These results suggests that recurrent UTIs can have lasting impact on the brain, and it warrants further investigation of the potential role of UTIs in the disease progression of synucleinopathies and related neurological disorders.
Authors
- Wouter Peelaerts (ORCID: https://orcid.org/0000-0003-3776-4162)
- Ehsan Arkin (ORCID: https://orcid.org/0009-0006-9109-0380)
- Thomas J. Hannan (ORCID: https://orcid.org/0000-0003-0498-8231)
- Wanli W. Smith (ORCID: https://orcid.org/0000-0002-6482-5154)
- Anna Barber Janer (ORCID: https://orcid.org/0000-0002-8752-9665)
- Gabriela Mercado (ORCID: https://orcid.org/0000-0002-3346-5758)
- Patrik Brundin (ORCID: https://orcid.org/0000-0003-2924-5186)
- Jennifer A. Steiner (ORCID: https://orcid.org/0000-0003-0953-1310)
- Dieter Plessers (ORCID: https://orcid.org/0000-0001-8906-8447)
- Ann-Céline Clabout
- Vanessa Howland
Institutions
- Roche (Switzerland) (CH)
- Van Andel Institute (US)
- Johns Hopkins University (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1177/1877718x241289046
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- Farmer Family Foundation
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Université Paris-Est Créteil Val-de-Marne
- Vlaamse regering