Complex Genetic Evolution and Treatment Challenges in Myeloid Neoplasms: A Case of Persistent t(2;3)(p15~23;q26)/<i>MECOM</i>Rearrangement,<i>SF3B1</i>Mutation, and Transient<i>TNIP1::PDGFRB</i>Chimera
This case highlights the complexity of MDS and the importance of genetic abnormalities in treatment planning. Persistent MECOM rearrangement and the TNIP1::PDGFRB chimera emphasize the need for further research into resistance mechanisms.
Authors
- Geir E. Tjønnfjord (ORCID: https://orcid.org/0000-0002-7757-4091)
- Malu Lian Hestdalen
- Signe Spetalen (ORCID: https://orcid.org/0000-0002-2426-5316)
- Ioannis Panagopoulos (ORCID: https://orcid.org/0000-0003-2159-5341)
- Kristin Andersen
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Norwegian Cancer Society (NO)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2024-12-27
- DOI
- https://doi.org/10.21873/cgp.20483
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00