Solvent‐Directed Regioselective Cascade Reaction with Diazo Compounds
Abstract A tandem system comprising cyclization reaction of diazo compound and cross‐coupling of the other one has been developed. This provides facile access to pyrazoles and there derivatives with high levels of regioselectivity in moderate to good yields. This process uniquely utilizes CF 3 CH 2 OTf both as a solvent and a catalyst under mild conditions. Mechanistic studies provide insights into the intricate sequence involved in the formation of pyrazoles and further selective cross‐coupling with another diazo compound.
Authors
- Shuang-Xi Gu
- Jie Liao
- Jie Zeng (ORCID: https://orcid.org/0000-0002-8812-0298)
- Haifeng Wang (ORCID: https://orcid.org/0009-0003-7042-188X)
- Yufan Chen (ORCID: https://orcid.org/0000-0001-7989-3283)
- Chih‐Hung Wang (ORCID: https://orcid.org/0000-0001-5058-4356)
- Lewan Li
- Jian Lv (ORCID: https://orcid.org/0000-0001-7641-5411)
- Fener Chen
- Menghua Dong
Institutions
- Fudan University (CN)
- Ministry of Education (SA)
- Scientific Research Institute of Organic Intermediates and Dyes (RU)
- Instytut Farmaceutyczny (PL)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ejoc.202401336
- Citations
- 1
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25