Is the 99th Percentile Cutoff Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome
The clinical utility of 99th percentile cutoffs is assay dependent. For QL, these cutoffs were unsuitable, while Aptiva showed better alignment with clinical thresholds. Manufacturer-recommended cutoffs, supported by extensive validation, offer a reliable alternative when clinical studies are infeasible.
Authors
- Michael Mähler (ORCID: https://orcid.org/0000-0002-7919-0948)
- Brandon S. Walker (ORCID: https://orcid.org/0000-0003-0995-3409)
- Vijayalakshmi Nandakumar
- Abdulrahman Saadalla (ORCID: https://orcid.org/0000-0002-3175-3967)
- Dipanwita Banerjee (ORCID: https://orcid.org/0000-0001-5907-9583)
- Alexis Dadelahi
Institutions
- University of Utah (US)
- ARUP Institute for Clinical and Experimental Pathology
- ARUP Laboratories (United States) (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1093/jalm/jfae149
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00