Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement
Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted in the past 2 decades. Although open/incisional biopsies used to be the predominant approach to obtain diagnostic material for Ewing sarcoma and osteosarcoma, image-guided core needle biopsies have increased in frequency and are safe for patients. These procedures are less invasive and reduce recovery times but have potential limitations. The quantity and quality of tissue obtained through these procedures vary between institutions. Acquired viable tissue volumes can be low, limiting the conduct of downstream expanded clinical workup, molecular analyses, and research. Patients with advanced Ewing sarcoma and osteosarcoma continue to have overall poor outcomes despite dose-intensive cytotoxic chemotherapy. The biology of treatment resistance is not currently well understood, partly due to limited availability of relevant tissue to study. There is a need for access to quality tumor specimens for molecular and other analyses to identify high-risk tumor subsets and drive discovery to improve patient outcomes. Given broad variability in bone tumor tissue procurement and processing across member institutions, the Children's Oncology Group Bone Tumor Committee convened a multidisciplinary group of experts to outline the current and near-future tissue needs for optimal clinical care and access to research platforms. The goal of this working group was to provide high-level guidance on biopsy practices that safely meet these evolving needs. Harmonizing tissue collection practices is paramount to improving the care of children, adolescents, and young adults diagnosed with Ewing sarcoma and osteosarcoma.
Authors
- Steven G. DuBois (ORCID: https://orcid.org/0000-0003-0882-738X)
- Emily Kanaya Slotkin (ORCID: https://orcid.org/0000-0002-4463-5759)
- Safia K. Ahmed (ORCID: https://orcid.org/0000-0003-2482-594X)
- Brian T. Craig (ORCID: https://orcid.org/0000-0002-9066-7305)
- Holcombe E. Grier (ORCID: https://orcid.org/0009-0001-7701-2304)
- Christine M. Heske (ORCID: https://orcid.org/0000-0003-0956-6249)
- David S. Shulman (ORCID: https://orcid.org/0000-0002-5994-2604)
- Elizabeth R. Lawlor (ORCID: https://orcid.org/0000-0002-2350-1540)
- Sarah Cohen‐Gogo (ORCID: https://orcid.org/0000-0002-8852-1104)
- Ryan D. Roberts (ORCID: https://orcid.org/0000-0001-5028-744X)
- Michael S. Isakoff (ORCID: https://orcid.org/0000-0003-4790-9919)
- Patrick J. Grohar (ORCID: https://orcid.org/0000-0002-1071-4563)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- Jessica L. Davis (ORCID: https://orcid.org/0000-0002-2725-1518)
- C. Matthew Hawkins (ORCID: https://orcid.org/0000-0003-1086-6783)
- Jesse K. Sandberg (ORCID: https://orcid.org/0000-0001-9980-8859)
- Alyaa Al‐Ibraheemi (ORCID: https://orcid.org/0000-0003-1769-7839)
- Ajay Gupta (ORCID: https://orcid.org/0000-0001-6074-9847)
- David S. Geller (ORCID: https://orcid.org/0000-0002-4549-7124)
- Nicole I. Montgomery
- Katherine A. Janeway (ORCID: https://orcid.org/0000-0001-6000-3594)
- Daniel J. Indelicato (ORCID: https://orcid.org/0000-0001-5765-1873)
- Odion T. Binitie (ORCID: https://orcid.org/0000-0002-2674-9939)
- Leo Mascarenhas (ORCID: https://orcid.org/0000-0001-7790-0777)
- Kelly M. Bailey (ORCID: https://orcid.org/0000-0003-3925-3243)
- Elyssa Rubin
- Matthew S. Dietz (ORCID: https://orcid.org/0000-0002-0398-5840)
- Susan L. Whiteway (ORCID: https://orcid.org/0000-0003-3496-6252)
- Mark Krailo (ORCID: https://orcid.org/0000-0002-7608-0698)
- Catherine M. Albert (ORCID: https://orcid.org/0000-0002-8101-9066)
- Roshni Dasgupta
Institutions
- University of Southern California (US)
- Children's Hospital of Wisconsin (US)
- Cedars-Sinai Medical Center (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Roswell Park Comprehensive Cancer Center (US)
- Seattle Children's Hospital (US)
- National Institutes of Health (US)
- Albert Einstein College of Medicine (US)
- Children's Hospital of Orange County (US)
- Nationwide Children's Hospital (US)
- Primary Children's Hospital (US)
- Lucile Packard Children's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- University of Utah (US)
- Walter Reed National Military Medical Center (US)
- Hospital for Sick Children (CA)
- Moffitt Cancer Center (US)
- University of Florida (US)
- Connecticut Children's Medical Center (US)
- Center for Cancer and Blood Disorders (US)
- Mayo Clinic Hospital (US)
- Children's Hospital of Pittsburgh (US)
- Children's Hospital at Montefiore (US)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Children's Healthcare of Atlanta (US)
- Texas Children's Hospital (US)
- Boston Children's Museum (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2024-12-27
- DOI
- https://doi.org/10.6004/jnccn.2024.7063
- Citations
- 7
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Institutes of Health
- National Cancer Institute