D-Mannose-Mediated metabolic pathways sustain the molecular signatures of sperm function and fertilization
This study identifies key molecular signatures of fertilization-competent sperm and highlights D-mannose as a novel modulator of sperm quality and function. These findings provide valuable insights into sperm biology and propose innovative therapeutic strategies for treating male infertility and optimizing assisted reproduction technologies.
Authors
- Wenlong Zhao (ORCID: https://orcid.org/0000-0002-6002-7091)
- Ni-Hao Gu (ORCID: https://orcid.org/0000-0002-4910-6813)
- Xian-Hua Lin (ORCID: https://orcid.org/0000-0003-0002-6414)
- Hefeng Huang (ORCID: https://orcid.org/0000-0003-4344-8019)
- Xueyuan Liu
- Jian‐Zhong Sheng (ORCID: https://orcid.org/0000-0001-8006-3965)
- Ningxin Qing
Institutions
- International Peace Maternity & Child Health Hospital (CN)
- Hangzhou Women’s Hospital (CN)
- Zhejiang Hospital (CN)
- Ministry of Education (TH)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.jare.2024.12.035
- Citations
- 2
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Clinical Research Center