Oxidative Monofluorination of 1,4-Diiodo(or Dibromo)-2,3,5,6-tetramethylbenzenes in the System PbO₂—HF—Py—CH₂Cl₂
The oxidation of 1,4-diiodo-2,3,5,6-tetramethylbenzene (diiododurene) and 1,4-dibromo-2,3,5,6-tetramethylbenzene (dibromodurene) by lead dioxide PbO₂ in Olah reagent, hydrogen fluoride-pyridine mixture, with CH₂Cl₂ as a co-solvent at room temperature for 96 h results in the corresponding products of monofluorination of methyl group. This is the first example of using the oxidative system PbO₂—HF—Py—CH₂Cl₂ for side-chain monofluorination of methylated benzenes.
Authors
- Aleksander V. Vasilyev (ORCID: https://orcid.org/0000-0003-3628-1492)
- Mikhail V. Kalyaev (ORCID: https://orcid.org/0000-0002-4329-5131)
- Dmitry S. Ryabukhin (ORCID: https://orcid.org/0000-0001-5345-0038)
Institutions
- St Petersburg University (RU)
- All-Russian Scientific Research Institute of Refrigeration Industry (RU)
- Saint Petersburg State Forest Technical University (RU)
Publication Details
- Journal
- Журнал органической химии
- Published
- 2024-12-27
- DOI
- https://doi.org/10.31857/s0514749224020011
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00