European standard clinical practice recommendations for paediatric high-grade gliomas

<h2>Abstract</h2> Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. This guideline was written by members of the SIOPE HGG Working Group as part of the European Standard Clinical Practice (ESCP) Project of the European Reference Network for Paediatric Oncology, ERN PaedCan. The guideline aims to integrate available evidence-based and expert opinion-based information to assist healthcare professionals in the management of pedHGGs and in an attempt to provide equity in healthcare reflecting the varying resources of each European country.

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Publication Details

Journal
EJC Paediatric Oncology
Published
2024-12-27
DOI
https://doi.org/10.1016/j.ejcped.2024.100210
Citations
6
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
2.63

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article

European standard clinical practice recommendations for paediatric high-grade gliomas

Christof M. Kramm, Uri Tabori, Darren Hargrave, G Giraud et al.
6 citations
EJC Paediatric Oncology
Glioma Diagnosis and Treatment
2.63
article

European standard clinical practice recommendations for paediatric high-grade gliomas

Christof M. Kramm, Uri Tabori, Darren Hargrave, G Giraud, Brigitte Bison, Rejin Kebudi, David C. Mulligan, Shivaram Avula, Thankamma Ajithkumar, Stéphanie Bolle, Mechthild Krause, Maria João Gil‐da‐Costa, Pelle Nilsson, Anirban Das, Elwira Szychot, Jacques Grill, Maarten H. Lequin, Torsten Pietsch, Pieter Wesseling, Giovanni Morana, Veronica Biassoni, Sophie E. M. Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Yasmin Lassen–Ramshad, Thomas S. Jacques, Kristian Aquilina, Pascale Varlet, Geert O. Janssens, Ulrike Löbel, Maura Massimino, David Jones, Ulrich W. Thomale, Dannis van Vuurden, Sami Bui Quy Abu Hamdeh, Francesca Kozmann, André O. Von Büren
article en
6 citations

Abstract

<h2>Abstract</h2> Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. This guideline was written by members of the SIOPE HGG Working Group as part of the European Standard Clinical Practice (ESCP) Project of the European Reference Network for Paediatric Oncology, ERN PaedCan. The guideline aims to integrate available evidence-based and expert opinion-based information to assist healthcare professionals in the management of pedHGGs and in an attempt to provide equity in healthcare reflecting the varying resources of each European country.

EJC Paediatric OncologyVol. 5
Uppsala University (SE), Uppsala University Hospital (SE), University of Bonn (DE), University of Trieste (IT), University of Augsburg (DE), German Cancer Research Center (DE), Aarhus University (DK), Heidelberg University (DE), Great Ormond Street Hospital for Children NHS Foundation Trust (GB), Cancer Research UK (GB), Hospital for Sick Children (CA), Institut Gustave Roussy (FR), Aarhus University Hospital (DK), Cambridge University Hospitals NHS Foundation Trust (GB), Hospital de São João (PT), Alder Hey Children's NHS Foundation Trust (GB), University Hospital of Geneva (CH), DC Cancer Consortium (US), Development Fund (NO), Centre Hospitalier Sainte-Anne (FR), Princess Máxima Center (NL), Amsterdam University Medical Centers (NL), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), University College London (GB), University of Turin (IT), Istanbul University (TR), University of Göttingen (DE), Charité - Universitätsmedizin Berlin (DE), Pomeranian Medical University (PL)
Cancer Research UK, National Institute for Health and Care Research, CHILDREN with CANCER UK, Great Ormond Street Hospital Charity, Great Ormond Street Institute of Child Health
Openalex Percentile: Top 9%
Glioma Diagnosis and Treatment
2.63
DOIOpen Access PDFOpenAlex
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