Carboxylic Acid‐Catalysed Transamidation of Boc‐Protected Diketopiperazines (Boc‐DKPs) for Peptide Synthesis
Abstract A carboxylic acid‐catalysed transamidation of Boc‐protected diketopiperazines (Boc‐DKPs) was developed in this study, which allowed access to various tripeptides featuring a D‐proline residue in good‐to‐high yields within 30 min. Subsequent coupling reactions between the Boc‐DKPs and di‐, tri‐, and tetrapeptide esters were successfully performed, furnishing the corresponding tetra‐, penta‐, and hexapeptides.
Authors
- Kazumasa Kon (ORCID: https://orcid.org/0000-0002-9661-0908)
- Hisashi Yamamoto (ORCID: https://orcid.org/0000-0003-1687-7029)
Institutions
- Chubu University (JP)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ejoc.202401319
- Citations
- 3
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Cosmetology Research Foundation
- Japan Society for the Promotion of Science