Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene
Collectively, downregulation of IGF2BP2 could overcome DDP resistance in LC through declining the Spon2 gene expression in an m6A-dependent manner. These results may provide a new strategy for overcoming DDP resistance in LC.
Authors
- Ting Dou (ORCID: https://orcid.org/0000-0003-4708-9623)
- Zhenfei Wang (ORCID: https://orcid.org/0000-0003-0563-6318)
- Hong Li (ORCID: https://orcid.org/0000-0001-5679-9980)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-9179-236X)
- Hongfang Yu
- Hao Yang (ORCID: https://orcid.org/0009-0005-8623-8531)
- Shilei Zhang (ORCID: https://orcid.org/0000-0002-2966-5140)
- Jingwen Yang (ORCID: https://orcid.org/0000-0002-8206-2584)
- Liping Sun (ORCID: https://orcid.org/0000-0003-1993-8544)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1186/s41065-024-00360-w
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia