Distinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer
Our findings identify previously unknown links between intestinal microbiota alterations, metabolites, and host genomics in RCC vs. LCC, suggesting that it may be possible to treat colorectal cancer (CRC) by targeting the gut microbiota-host interaction. Video Abstract.
Authors
- Yongzhi Yang (ORCID: https://orcid.org/0000-0001-6912-6718)
- Debing Shi
- Cheng Kong (ORCID: https://orcid.org/0000-0002-3698-991X)
- Yanlei Ma (ORCID: https://orcid.org/0000-0002-0632-5258)
- Guan Wang (ORCID: https://orcid.org/0000-0002-4341-3468)
- Jinming Li (ORCID: https://orcid.org/0000-0002-1476-3397)
- Liang Lei (ORCID: https://orcid.org/0000-0001-5919-0898)
- Qinying Wang (ORCID: https://orcid.org/0000-0002-4149-5607)
- Jinwang Wei
- Guang Liu (ORCID: https://orcid.org/0009-0000-8582-9624)
- Xinxiang Li
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Hai Kang Life (China) (CN)
- GenomiCare (China) (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1186/s40168-024-01987-7
- Citations
- 18
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China
- Fudan University