Diagnostic abnormalities, disease severity and immunotherapy responsiveness in individuals with Down syndrome regression disorder
In a population of individuals diagnosed with DSRD, abnormalities in serum cytokine levels, neuroimaging findings, and CSF analysis emerged as indicators of disease severity and responsiveness to immunotherapy.
Authors
- Eileen A. Quinn
- Benjamin N. Vogel
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Saba Jafarpour (ORCID: https://orcid.org/0000-0001-8029-785X)
- Laura Keehan (ORCID: https://orcid.org/0009-0005-3084-679X)
- Jonathan Douglas Santoro (ORCID: https://orcid.org/0000-0002-8350-8234)
- Deepti Nagesh (ORCID: https://orcid.org/0000-0002-4928-0782)
- Aaron D. Besterman (ORCID: https://orcid.org/0000-0002-8671-1203)
- Mellad Khoshnood (ORCID: https://orcid.org/0000-0003-2232-8341)
- Noemi Alice Spinazzi (ORCID: https://orcid.org/0000-0001-5009-7670)
- Lina Nguyen
- Lilia Kazerooni (ORCID: https://orcid.org/0009-0003-4147-5395)
- Natalie K. Boyd
- Melanie Manning
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- University of California, San Francisco (US)
- University of California San Diego (US)
- UCSF Benioff Children's Hospital (US)
- University of Toledo (US)
- Stanford University (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1038/s41598-024-81819-8
- Citations
- 5
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development