Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet‐Induced Obese Mice
Our findings indicate that global deletion of Hdac9 prevented the development of obesity, hepatic steatosis, and WAT inflammation and fibrosis in male mice with diet-induced obesity and MASH, suggesting that a sex-dependent role of HDAC9 may exist in the pathways mentioned above.
Authors
- Young‐Ki Park (ORCID: https://orcid.org/0000-0003-3503-5847)
- Mi‐Bo Kim (ORCID: https://orcid.org/0000-0002-0217-0244)
- Hyungryun Jang
- Olivia Corvino
- Hyun‐Ju Kang (ORCID: https://orcid.org/0000-0002-2129-1658)
- Tho X. Pham
- Siqi Hu (ORCID: https://orcid.org/0000-0002-6171-4635)
- Ji‐Young Lee (ORCID: https://orcid.org/0000-0002-7945-793X)
- Yoojin Lee (ORCID: https://orcid.org/0000-0003-2475-5857)
- Minkyung Bae
- Joan A. Smyth (ORCID: https://orcid.org/0000-0002-8879-6474)
Institutions
- University of Connecticut (US)
- Yonsei University (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1111/jgh.16856
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases