SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction
In cardiac fibroblasts, SALL4 mediates the DOT1L/H3K79me2 signaling pathway to inhibit SHP2, which then promotes the YAP/TAZ signaling pathway, thereby facilitating the progression of myocardial infarction.
Authors
- Yanhong Zong
- Yanqing Tie
- Kenan Peng
- Zhipeng Tang (ORCID: https://orcid.org/0000-0001-5695-8072)
- He Tan
- Ming Zhao
Institutions
- Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1038/s41598-024-81815-y
- Citations
- 3
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.70