Association between maternal usage of volatile organic compounds and West syndrome, the Japan Environment and Children’s study
Multiple etiologies of West syndrome have been reported; however, there are cases of unknown etiologies. Exposure to volatile organic compounds (VOCs) increases the risk of epilepsy; however, their effects on children remain unknown. This study aimed to investigate the association between maternal occupational usage of VOCs and West syndrome development in children. Using data from a cohort of 88,280 children, we extracted children born to mothers who had used VOCs during pregnancy. Based on an epilepsy diagnosis by the age of 2 years, the frequency of usage of VOCs was comparatively analyzed among the following groups: never diagnosed with epilepsy, West syndrome, and other epileptic syndromes. A total of 15, 154, and 88,111 children were categorized into the West syndrome, other epileptic syndrome, and never diagnosed with epilepsy groups, respectively. The odds ratio (OR) for West syndrome development increased with the frequency of permanent marker usage (one to three times a month: OR = 2.58, 95% confidence interval [CI] 0.75-8.90; one or more times a week: OR = 4.34, 95% CI 1.23-15.26). These results suggested an association between maternal occupational frequent usage of permanent marker and West syndrome development in children.
Authors
- Takafumi Nishioka
- Nobuo Yaegashi (ORCID: https://orcid.org/0000-0003-2521-039X)
- Koichi Hashimoto (ORCID: https://orcid.org/0000-0002-4473-2698)
- Masayuki Shima (ORCID: https://orcid.org/0000-0002-8783-7879)
- Hidekuni Inadera (ORCID: https://orcid.org/0000-0002-3548-221X)
- Sachi Tokunaga (ORCID: https://orcid.org/0000-0001-7892-5968)
- Narumi Tokuda
- Hideki Shimomura (ORCID: https://orcid.org/0000-0002-0815-9193)
- Yukihiro Ohya (ORCID: https://orcid.org/0000-0002-1560-3942)
- Tetsuro Fujino (ORCID: https://orcid.org/0009-0003-1496-0192)
- Masumi Okuda (ORCID: https://orcid.org/0000-0001-5263-2868)
- Reiko Kishi
- Zentaro Yamagata
- Takeo Nakayama (ORCID: https://orcid.org/0000-0002-7918-6252)
- Chisato Mori (ORCID: https://orcid.org/0000-0002-1144-8316)
- Takahiko Katoh
- Tomotaka Sobue (ORCID: https://orcid.org/0000-0003-2817-3483)
- Narufumi Suganuma (ORCID: https://orcid.org/0000-0003-1610-6216)
- Seiji Kageyama (ORCID: https://orcid.org/0000-0002-5220-6137)
- Michihiro Kamijima (ORCID: https://orcid.org/0000-0003-0670-8790)
- Yasuhiro Takeshima (ORCID: https://orcid.org/0000-0002-6468-7185)
- Shuichi Ito (ORCID: https://orcid.org/0000-0002-5242-8987)
- Yohei Taniguchi (ORCID: https://orcid.org/0000-0003-3570-4756)
- Shin Yamazaki (ORCID: https://orcid.org/0000-0002-2309-2425)
- Naoko Taniguchi (ORCID: https://orcid.org/0000-0002-7054-1676)
- S. Ohaga
Institutions
- Fukushima Medical University (JP)
- Kyushu University (JP)
- Hyogo Medical University (JP)
- Chiba University (JP)
- National Institute for Environmental Studies (JP)
- Tohoku University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Tottori University Hospital (JP)
- National Center For Child Health and Development (JP)
- University of Toyama (JP)
- University of Yamanashi (JP)
- Kōchi University (JP)
- Hyogo University (JP)
- Yokohama City University (JP)
- Kumamoto University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1038/s41598-024-81913-x
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of the Environment, Government of Japan