Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy
Lipotoxicity-induced FIS1 upregulation exacerbates mitochondrial fragmentation through its interaction with DRP1, leading to increased mitoROS production and the initiation of NLRP3-dependent pyroptosis in DbCM. Therefore, targeting FIS1 emerges as a potential therapeutic approach for managing DbCM.
Authors
- Qingrui Wu
- Qingyu Xiao (ORCID: https://orcid.org/0000-0002-0475-2416)
- Z Y Deng
- Yuqiong Chen (ORCID: https://orcid.org/0000-0001-7592-5989)
- Jijin Lin
- Libo Luo (ORCID: https://orcid.org/0000-0002-5645-2175)
- Chaochao Cen
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Chest Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2024.12.049
- Citations
- 12
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Guangzhou Science and Technology Program key projects