Replacing rifampicin with minocycline increases the activity of the treatment regimen for Mycobacterium avium complex pulmonary disease in a dynamic hollow-fibre system
Replacing rifampicin with minocycline increased the antimycobacterial activity of the MAC-PD treatment regimen in the hollow-fibre model, without jeopardizing the prevention of macrolide-resistance. This promising minocycline-containing regimen is a candidate for inclusion in clinical trials.
Authors
- Jakko van Ingen (ORCID: https://orcid.org/0000-0002-0581-2003)
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- J. A. M. Raaijmakers (ORCID: https://orcid.org/0000-0001-7250-5647)
- Wouter Hoefsloot (ORCID: https://orcid.org/0000-0003-1007-1075)
- Heiman Wertheim (ORCID: https://orcid.org/0000-0002-5003-5565)
- Mike Marvin Ruth (ORCID: https://orcid.org/0000-0003-0281-4895)
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
- Jodie A. Schildkraut (ORCID: https://orcid.org/0000-0002-7236-8934)
- Erik van den Hombergh (ORCID: https://orcid.org/0009-0005-8494-4424)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1016/j.ijantimicag.2024.107423
- Citations
- 2
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Radboud Institute for Health Sciences