Excessive accumulation of thioredoxin promotes osteogenic differentiation of mesenchymal stem cells of ligament in ankylosing spondylitis by upregulating autophagy levels
Abnormal TXN expression in the immune system is closely associated with the development of pathological ossification in ankylosing spondylitis. Future research should aim to elucidate the underlying mechanisms, with the inhibition of TXN production emerging as a promising strategy for preventing spinal ligament ossification in this condition.
Authors
- Junjie Qiao (ORCID: https://orcid.org/0000-0001-6426-2024)
- Changhao Han
- Qianqian Xu (ORCID: https://orcid.org/0000-0002-8454-6187)
- Weidong Xu (ORCID: https://orcid.org/0000-0001-6477-9461)
- Bole Zhou
- Xinzhe Feng (ORCID: https://orcid.org/0000-0003-4176-494X)
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.bbrc.2024.151255
- Citations
- 2
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Changhai Hospital of Shanghai