Integrating Fundamental Biology and Translational Potential: Advancing the Frontiers of Membrane Biology through Dynamic Modulation of Cellular Membranes Proteins

Cellular membranes are highly dynamic structures that undergo constant remodeling to support a variety of cellular processes, including signaling, endocytosis, vesicle trafficking, and cell migration. This dynamic behavior is largely regulated by the interactions between phospholipids, which form the lipid bilayer, and membrane-deforming proteins, which induce changes in membrane curvature and shape. Phospholipids such as phosphatidylcholine, phosphatidylinositol, and phosphatidylserine provide structural stability to the membrane and act as signaling molecules that modulate membrane dynamics. Membrane-deforming proteins, including BAR-domain proteins (Bin/Amphiphysin/Rvs domain), Clathrin, and dynamin, interact with phospholipids to bend, pinch, or remodel the membrane, facilitating vesicle formation and endocytosis. The coordinated action between phospholipids and membrane-deforming proteins is crucial for cellular functions such as membrane repair, signal transduction, and cell motility. This review explores the roles of these two key components in the dynamic modulation of cellular membranes and their importance in maintaining cellular homeostasis. Understanding these interactions may provide insights into diseases associated with membrane dysfunction, offering potential therapeutic targets.