G Protein-coupled Estrogen Receptor 1 (GPER1) Regulates Expression of<i>SERPINE1</i>/PAI-1 and Inhibits Tumorigenic Potential of Cervical Squamous Cell Carcinoma Cells<i>In Vitro</i>
Activation of GPER1 reduces clonogenicity and migration of CSCC cells and suppresses expression of SERPINE1/PAI-1. Suppression of SERPINE1/PAI-1 in CSCC cells reduces tumorigenic potential. GPER1 may be a suitable target for suppression of SERPINE1/PAI-1 in CSCC. However, SERPINE1/PAI-1 does not appear to be the decisive factor for GPER1-regulated cell migration.
Authors
- Carsten Gründker (ORCID: https://orcid.org/0000-0001-8828-7955)
- Julia Gallwas (ORCID: https://orcid.org/0000-0001-9640-1973)
- SOPHIA RUCKRIEGL
- LINEA RÖRIG
Institutions
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2024-12-27
- DOI
- https://doi.org/10.21873/cgp.20482
- Citations
- 3
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 1.65