<i>Pseudomonas aeruginosa</i> alkyl quinolone response is dampened by <i>Enterococcus faecalis</i>
While we now appreciate that many infections are polymicrobial, we understand little of the specific actions between a given set of microbes to enable combinatorial survival and pathogenesis. The bacteria <i>Pseudomonas aeruginosa</i> and <i>Enterococcus faecalis</i> are both prevalent pathogens in wound, urinary tract, and bacteremic infections. While <i>P. aeruginosa</i> often kills other species in standard laboratory culture conditions, we present here that <i>E. faecalis</i> can be reliably co-cultured with <i>P. aeruginosa</i>. We specifically detail that ornithine produced by <i>E. faecalis</i> reduces the <i>Pseudomonas</i> quinolone signal response of <i>P. aeruginosa</i>. This reduction of the <i>Pseudomonas</i> quinolone signal response aids <i>E. faecalis</i> growth.
Authors
- Jonathan V. Sweedler (ORCID: https://orcid.org/0000-0003-3107-9922)
- Abigail A. Weaver (ORCID: https://orcid.org/0000-0003-3757-2902)
- Jon E. Paczkowski (ORCID: https://orcid.org/0000-0002-8286-3808)
- Joshua D. Shrout (ORCID: https://orcid.org/0000-0001-9509-2187)
- Maggie M. Fink
- Dharmeshkumar Parmar (ORCID: https://orcid.org/0000-0001-7956-7429)
- Lingyun Li (ORCID: https://orcid.org/0000-0001-7804-6269)
- Ella A. Junker
- Maggie K. Klaers
- Elizabeth A. Jarocki
Institutions
- University of Notre Dame (US)
- New York State Department of Health (US)
- Wadsworth Center (US)
- University of Illinois Urbana-Champaign (US)
- University at Albany, State University of New York (US)
Publication Details
- Journal
- mBio
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1128/mbio.03320-24
- Citations
- 5
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Science Foundation
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases